The cytoadherence linked asexual gene family of Plasmodium falciparum:: are there roles other than cytoadherence?

被引：45

作者：

Holt, DC ^{[1
]}

Gardiner, DL ^{[1
]}

Thomas, EA ^{[1
]}

Mayo, M ^{[1
]}

Bourke, PF ^{[1
]}

Sutherland, CJ ^{[1
]}

Carter, R ^{[1
]}

Myers, G ^{[1
]}

Kemp, DJ ^{[1
]}

Trenholme, KR ^{[1
]}

机构：

[1] Menzies Sch Hlth Res, Casuarina, NT 0811, Australia

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1999年 / 29卷 / 06期

关键词：

Plasmodium falciparum; clag; gene family; cytoadherence; PfEMPI; CD36;

D O I：

10.1016/S0020-7519(99)00046-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The binding of erythrocytes infected with Plasmodium falciparum to the endothelium lining the small blood vessels of the brain and other organs can mediate severe pathology. A region at the right end of chromosome 9 has been implicated in the binding of parasitised erythrocytes to the endothelial receptor CD36. A gene expressed in asexual erythrocytic stage parasites has been identified in this region and termed the cytoadherence linked asexual gene (clag). Antisense RNA production and targeted gene disruption of clag resulted in greatly reduced binding to CD36. Hybridisation to 3D7 chromosomes showed clag to be a part of a gene family of at least nine members. All members analysed so far have a conserved gene structure of at least nine exons, as well as putative transmembrane domains. The possible functions of the gene family are discussed. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

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页码：939 / 944

页数：6

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