Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer

被引：128

作者：

Nicholson, RI ^{[1
]}

McClelland, RA

Robertson, JFR

Gee, JMW

机构：

[1] Cardiff Univ, Tenovus Canc Res Ctr, Cardiff CF4 4XX, S Glam, Wales

[2] City Hosp, Dept Surg, Nottingham NG5 1PB, England

来源：

关键词：

D O I：

10.1677/erc.0.0060373

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple lines of evidence implicate steroid hormone and growth factor cross-talk as a modulator of endocrine response in breast cancer and that aberrations in growth factor signaling pathways are a common element in the endocrine resistant phenotype. Delineation of these relationships is thus an important diagnostic goal in cancer research, while the targeting of aberrant growth factor signaling holds the promise of improving therapeutic response rates.

引用

页码：373 / 387

页数：15

共 164 条

[1] Agadir A, 1997, CANCER RES, V57, P3444
[2] PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO
ALESSI, DR
CUENDA, A
COHEN, P
DUDLEY, DT
SALTIEL, AR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) : 27489 - 27494
[3] MODULATION OF TRANSCRIPTIONAL ACTIVATION BY LIGAND-DEPENDENT PHOSPHORYLATION OF THE HUMAN ESTROGEN RECEPTOR-A/B REGION
ALI, S
METZGER, D
BORNERT, JM
CHAMBON, P
[J]. EMBO JOURNAL, 1993, 12 (03) : 1153 - 1160
[4] Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
Amundadottir, LT
Leder, P
[J]. ONCOGENE, 1998, 16 (06) : 737 - 746
[5] EXPRESSION OF RAS P21, P53 AND C-ERBB-2 IN ADVANCED BREAST-CANCER AND RESPONSE TO FIRST LINE HORMONAL-THERAPY
ARCHER, SG
ELIOPOULOS, A
SPANDIDOS, D
BARNES, D
ELLIS, IO
BLAMEY, RW
NICHOLSON, RI
ROBERTSON, JFR
[J]. BRITISH JOURNAL OF CANCER, 1995, 72 (05) : 1259 - 1266
[6] Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation
Arnold, SF
Melamed, M
Vorojeikina, DP
Notides, AC
Sasson, S
[J]. MOLECULAR ENDOCRINOLOGY, 1997, 11 (01) : 48 - 53
[7] SERINE-167 IS THE MAJOR ESTRADIOL-INDUCED PHOSPHORYLATION SITE ON THE HUMAN ESTROGEN-RECEPTOR
ARNOLD, SF
OBOURN, JD
JAFFE, H
NOTIDES, AC
[J]. MOLECULAR ENDOCRINOLOGY, 1994, 8 (09) : 1208 - 1214
[8] STIMULATION OF ESTROGEN RECEPTOR-MEDIATED TRANSCRIPTION AND ALTERATION IN THE PHOSPHORYLATION STATE OF THE RAT UTERINE ESTROGEN-RECEPTOR BY ESTROGEN, CYCLIC ADENOSINE-MONOPHOSPHATE, AND INSULIN-LIKE GROWTH FACTOR-I
ARONICA, SM
KATZENELLENBOGEN, BS
[J]. MOLECULAR ENDOCRINOLOGY, 1993, 7 (06) : 743 - 752
[9] PROLONGED TREATMENT OF BREAST-CANCER CELLS WITH ANTIESTROGENS INCREASES THE ACTIVATING PROTEIN-1-MEDIATED RESPONSE - INVOLVEMENT OF THE ESTROGEN-RECEPTOR
ASTRUC, ME
CHABRET, C
BALI, P
GAGNE, D
PONS, M
[J]. ENDOCRINOLOGY, 1995, 136 (03) : 824 - 832
[10] Badia Eric, 1995, Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales, V189, P755

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