Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion

被引：27

作者：

Kim, NK

Choi, YK

Kang, MS

Choi, DH

Cha, SH

An, MO

Lee, S

Jeung, M

Ko, JJ

Oh, D

机构：

[1] Pochon CHA Univ, Coll Med, Bundang CHA Gen Hosp, Inst Clin Res, Kyonggi Do 463712, South Korea

[2] Pochon CHA Univ, Coll Med, Bundang CHA Gen Hosp, Dept Diagnost, Kyonggi Do 463712, South Korea

[3] Pochon CHA Univ, Coll Med, Bundang CHA Gen Hosp, Dept Obstet & Gynecol, Songnam 463712, South Korea

[4] Pochon CHA Univ, Coll Med, Bundang CHA Gen Hosp, Infertil Med Ctr, Songnam 463712, South Korea

[5] Kongju Natl Univ, Dept Environm Educ, Kong Ju 314701, South Korea

[6] Pochon CHA Univ, Coll Med, Bundang CHA Gen Hosp, Dept Internal Med, Songnam 463712, South Korea

来源：

THROMBOSIS RESEARCH | 2006年 / 117卷 / 06期

关键词：

MTHFR; TSER; homocysteine; recurrent spontaneous abortion (RSA);

D O I：

10.1016/j.thromres.2005.05.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Methylenetetrahydrofolate reductase (MTHFR) mutations known to be associated with hyperhomocysteinemia may be a risk factor for recurrent spontaneous abortion. Recently 28-bp tandem repeat polymorphism in thymidylate synthase enhancer region (TSER) was reported to affect plasma homocysteine level. We investigated the association between plasma homocysteine level and MTHFR and TSER genotypes.

引用

页码：653 / 658

页数：6

共 28 条

[1] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].