The epidermal growth factor receptors and their family of ligands: Their putative role in atherogenesis

被引：132

作者：

Dreux, AC ^{[1
]}

Lamb, DJ ^{[1
]}

Modjtahedi, H ^{[1
]}

Ferns, GAA ^{[1
]}

机构：

[1] Univ Surrey, Sch Biomed & Mol Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England

来源：

ATHEROSCLEROSIS | 2006年 / 186卷 / 01期

关键词：

EGF; receptor; ErbB; 1; atherogenesis SMC; monocyte; macrophage;

D O I：

10.1016/j.atherosclerosis.2005.06.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The epidermal growth factor receptor is a member of type-I growth factor receptor family with tyrosine kinase activity that is activated following the binding of multiple cognate ligands. Several members of the EGF family of ligands are expressed by cells involved in atherogenesis. EGF receptor mediated processes have been well characterised within epithelial, smooth muscle and tumour cell lines in vitro, and the EGF receptor has been identified immunocytochemically on intimal smooth muscle cells within atherosclerotic plaques. There is also limited evidence for the expression of the EGF receptor family on leukocytes, although their function has yet to be clarified. In this review, we will discuss the biological functions of this receptor and its ligands and their potential to modulate the function of cells involved in the atherosclerotic process. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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页码：38 / 53

页数：16

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