Thrombosis triggered by severe arterial lesions is inhibited by oral administration of a glycoprotein IIb/IIIa antagonist

被引:11
作者
Badimon, JJ
Meyer, B
Feigen, LP
Baron, DA
Chesebro, JH
Fuster, V
Badimon, L
机构
[1] SEARLE, CARDIOVASC DIS RES, SKOKIE, IL USA
[2] SEARLE, PROD SAFETY ASSESSMENT, SKOKIE, IL USA
[3] UAB, HOSP SANTA CRUZ & SAN PABLO, CSIC, CARDIOVASC RES CTR, BARCELONA, SPAIN
关键词
IIb/IIIa receptor complex; platelet aggregation; platelets; thrombosis; xemilofiban;
D O I
10.1046/j.1365-2362.1997.1480697.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Platelet aggregation and thrombosis play an important role in the onset of acute coronary events. Regardless of the stimulus for activation, platelet thrombus formation is ultimately regulated through the IIb/IIIa receptor complex. The effects of oral administration of xemilofiban, a non-peptide mimetic of the RGDF sequence of the IIb/IIIa receptor complex, on thrombus formation were evaluated in a canine model. Xemilofiban significantly reduced platelet deposition on severely damaged arterial wall. Platelet deposition was reduced at both low (13 +/- 1 from 56 +/- 18 x 10(6) platelets cm(-2); P < 0.05) and high (23 +/- 2 from 111 +/- 21 x 10(?)6 platelets cm(-2); P < 0.01) shear rates. Platelet deposition was reduced to a monolayer as seen by electron microscopy (platelet-vessel wall interaction). Therefore, the availability of an orally active IIb/IIIa antagonist for chronic use may have significant value in preventing thrombus formation in those clinical situations associated with severe arterial injury. such as atherosclerotic plaque disruption.
引用
收藏
页码:568 / 574
页数:7
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