Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity

被引：170

作者：

Aton, Sara J. ^{[1
]}

Seibt, Julie ^{[1
]}

Dumoulin, Michelle ^{[1
]}

Jha, Sushil K. ^{[1
,2
]}

Steinmetz, Nicholas ^{[1
]}

Coleman, Tammi ^{[1
]}

Naidoo, Nirinjini ^{[3
]}

Frank, Marcos G. ^{[1
]}

机构：

[1] Univ Penn, Dept Neurosci, Sch Med, Philadelphia, PA 19104 USA

[2] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

[3] Univ Penn, Ctr Sleep & Resp Neurobiol, Sch Med, Philadelphia, PA 19104 USA

来源：

NEURON | 2009年 / 61卷 / 03期

基金：

美国国家卫生研究院;

关键词：

LONG-TERM POTENTIATION; HIPPOCAMPAL SYNAPTIC PLASTICITY; OCULAR DOMINANCE PLASTICITY; MEMORY CONSOLIDATION; VISUAL-CORTEX; DEVELOPMENTAL PLASTICITY; ORIENTATION SELECTIVITY; MONOCULAR DEPRIVATION; STRIATE CORTEX; EXPRESSION;

D O I：

10.1016/j.neuron.2009.01.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep is thought to consolidate changes in synaptic strength, but the underlying mechanisms are unknown. We investigated the cellular events involved in this process during ocular dominance plasticity (ODP)-a canonical form of in vivo cortical plasticity triggered by monocular deprivation (MD) and consolidated by sleep via undetermined, activity-dependent mechanisms. We find that sleep consolidates ODP primarily by strengthening cortical responses to non-deprived eye stimulation. Consolidation is inhibited by reversible, intracortical antagonism of NMDA receptors (NMDARs) or cAMP-dependent protein kinase (PKA) during post-MD sleep. Consolidation is also associated with sleep-dependent increases in the activity of remodeling neurons and in the phosphorylation of proteins required for potentiation of glutamatergic synapses. These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP.

引用

页码：454 / 466

页数：13

共 56 条

[1] Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: Are they effective or relevant? [J].

Albensi, Benedict C. ;

Oliver, Derek R. ;

Toupin, Justin ;

Odero, Gary .

EXPERIMENTAL NEUROLOGY, 2007, 204 (01) :1-13

[2]

BEAR MF, 1990, J NEUROSCI, V10, P909

[3] Orientation selectivity is reduced by monocular deprivation in combination with PKA inhibitors [J].

Beaver, CJ ;

Fischer, QS ;

Ji, QH ;

Daw, NW .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (04) :1933-1940

[4] Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex [J].

Beaver, CJ ;

Ti, QH ;

Fischer, QS ;

Daw, NW .

NATURE NEUROSCIENCE, 2001, 4 (02) :159-163

[5] Molecular basis of plasticity in the visual cortex [J].

Berardi, N ;

Pizzorusso, T ;

Ratto, GM ;

Maffei, L .

TRENDS IN NEUROSCIENCES, 2003, 26 (07) :369-378

[6] Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments [J].

Chen, C ;

Hardy, M ;

Zhang, J ;

LaHoste, GJ ;

Bazan, NG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 340 (02) :435-440

[7] Extensive and divergent effects of sleep and wakefulness on brain gene expression [J].

Cirelli, C ;

Gutierrez, CM ;

Tononi, G .

NEURON, 2004, 41 (01) :35-43

[8] Influence of binocular competition on the expression profiles of CRMP2, CRMP4, Dyn I, and Syt I in developing cat visual cortex [J].

Cnops, Lieselotte ;

Hu, Tjing-Tjing ;

Burnat, Kalina ;

Arckens, Lutgarde .

CEREBRAL CORTEX, 2008, 18 (05) :1221-1231

[9] Sleep does not enhance the recovery of deprived eye responses in developing visual cortex [J].

Dadvand, L. ;

Stryker, M. P. ;

Frank, M. G. .

NEUROSCIENCE, 2006, 143 (03) :815-826

[10] Fast-forward playback of recent memory sequences in prefrontal cortex during sleep [J].

Euston, David R. ;

Tatsuno, Masami ;

McNaughton, Bruce L. .

SCIENCE, 2007, 318 (5853) :1147-1150

← 1 2 3 4 5 6 →