Urotensin II evokes potent vasoconstriction in humans in vivo

被引：129

作者：

Böhm, F ^{[1
]}

Pernow, J ^{[1
]}

机构：

[1] Karolinska Hosp, Dept Cardiol, S-17176 Stockholm, Sweden

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2002年 / 135卷 / 01期

关键词：

blood flow; endothelin; forearm; urotensin; vasoconstriction;

D O I：

10.1038/sj.bjp.0704448

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The peptide urotensin II (U II) evokes potent vasoconstriction in non-human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation or no response. It is therefore of importance to determine the vascular effect of U II in humans in vivo. U II (0.1-300 pmol min(-1)) was infused into the brachial artery of nine healthy volunteers. Changes in forearm blood flow (FBF) were determined by venous occlusion plethysmography. U II induced dose-dependent reduction in FBF. A threshold response was obtained by 1 pmol min(-1), and the highest dose of U II (300 pmol min(-1)) reduced FBF by 31+/-4% (P<0.01). FBF returned to baseline values within 30 min. This study demonstrates that U II produces potent vasoconstriction in humans in vivo.

引用

页码：25 / 27

页数：3

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