Regulation of the ReIA (p65) transactivation domain

被引：63

作者：

O'Shea, John M. ^{[1
]}

Perkins, Neil D. ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Wellcome Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国惠康基金;

关键词：

co-activator; co-repressor; nuclear factor kappa B (NF-kappa B); p65; ReIA; transactivation;

D O I：

10.1042/BST0360603

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ReIA (p65) NF-kappa B (nuclear factor kappa B) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.

引用

页码：603 / 608

页数：6

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