Function of the ubiquitin-proteosome pathway in auxin response

被引:68
作者
del Pozo, JC [1 ]
Estelle, M [1 ]
机构
[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S1360-1385(99)01382-5
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Proteolysis of important regulatory proteins by the ubiquitin-proteosome pathway is a key aspect of cellular regulation in eukaryotes. Genetic studies in Arabidopsis indicate that response to auxin depends on the function of proteins in this pathway. The auxin transport inhibitor resistant 1 (TIR1) protein is part of a ubiquitin-protein-ligase complex (E3), known as SKP1 CDC53 F-box(TIR1) (SCFTIR1), that possibly directs ubiquitin-modification of protein regulators of the auxin response. In yeast, a similar E3 complex, SCFCDC4, is regulated by conjugation of the ubiquitin-related protein Rub1 to the Cdc53 protein. In Arabidopsis, the AUXIN-RESISTANT1 (AXR1) gene encodes a subunit of the RUB1-activating enzyme, the first enzyme in the RUB-conjugation pathway. Loss of AXR1 results in loss of auxin response. These results suggest a model in which RUB1 modification regulates the activity of SCFTIR1, thereby directing the degradation of the repressors of the auxin response.
引用
收藏
页码:107 / 112
页数:6
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