Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes

被引：154

作者：

Marcotorchino, Julie ^{[2
]}

Gouranton, Erwan ^{[2
]}

Romier, Beatrice ^{[2
]}

Tourniaire, Franck ^{[2
]}

Astier, Julien ^{[2
]}

Malezet, Christiane ^{[2
]}

Amiot, Marie-Josephe ^{[2
]}

Landrier, Jean-Francois ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, INRA, INSERM 1062, Fac Med,UMR 1260, F-13385 Marseille 5, France

[2] INSERM, Nutr Obes & Risk Thrombosis UMR1062, Marseille, France

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2012年 / 56卷 / 12期

关键词：

Adipocytes; Glucose uptake; Inflammation; Interleukins; Vitamin D;

D O I：

10.1002/mnfr.201200383

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Scope Obesity is strongly associated with low-grade inflammation, notably due to an overproduction of proinflammatory markers by adipose tissue and adipocytes as well as a vitamin D deficiency. Whether these problems are interrelated has not been clearly established. Methods and results In the present report, decreases in the levels of inflammatory markers such as IL-6, MCP-1, and IL-1 beta (mRNA and protein level) in human adipocytes and in 3T3-L1 adipocytes were observed after 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) treatment. Such treatment also decreased the expression of the TNF-alpha-mediated proinflammatory marker in 3T3-L1 and human adipocytes. A similar effect was observed in adipocyte-macrophage co-culture systems in which 1,25-(OH)2D3 decreased proinflammatory marker expression under basal and TNF-alpha-stimulated conditions. The involvement of VDR and NF-kappa B was confirmed in these regulations. Incubation with 1,25-(OH)2D3 also resulted in the dephosphorylation of p38, which is linked to the transcriptional induction of several Dusp family members. Functional consequences of the 1,25-(OH)2D3 treatment on glucose uptake and AKT phosphorylation were observed. Conclusion The improvement of both proinflammatory status and glucose uptake in adipocytes under 1,25-(OH)2D3 effect suggests that low-grade inflammation could be linked to vitamin D deficiency. This observation offers new perspectives in the context of obesity and associated physiopathological disorders.

引用

页码：1771 / 1782

页数：12

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