Quinine clearance in continuous venovenous hemofiltration

被引：10

作者：

Davies, JG ^{[1
]}

Greenwood, EF ^{[1
]}

Kingswood, JC ^{[1
]}

Sharpstone, P ^{[1
]}

Street, MK ^{[1
]}

机构：

[1] ROYAL SUSSEX CTY HOSP,DEPT INTENS CARE MED,INTENS THERAPY UNIT,BRIGHTON BN2 5BE,E SUSSEX,ENGLAND

来源：

ANNALS OF PHARMACOTHERAPY | 1996年 / 30卷 / 05期

关键词：

D O I：

10.1177/106002809603000511

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: To describe a case involving the removal of quinine by continuous venovenous hemofiltration (CVVH) in a patient with malaria and acute renal failure and to present recommendations on the dosing of quinine in such patients. CASE SUMMARY: A 50-year-old white man developed Plasmodium falciparum malaria following a visit to Nigeria. Although he received intravenous quinine, his condition deteriorated and he required intensive care management, including CVVH for the management of his acute renal failure. Quinine plasma concentrations were measured to determine both total body and extracorporeal clearance of the drug. DISCUSSION: To our knowledge this is the first report quantifying the removal of quinine by CVVH. The drug is not significantly removed by this extracorporeal process. The filter clearance accounted for less than 1.5% of the total body clearance. CONCLUSIONS: Initially the dosage of quinine administered to patients presenting with P. falciparum infection should not be reduced because of renal failure. This is particularly important when cerebral involvement is suspected. Subsequent dosage modification should reflect the severity of the patient's clinical condition and the plasma quinine concentration achieved, and should not be limited by the degree of renal impairment present.

引用

页码：487 / 490

页数：4

共 12 条

[1]

BICKLEY SK, 1988, CLIN PHARMACY, V7, P198

[2]

CLYDE DF, 1986, INFECT DIS MED MICRO, P1258

[3] QUANTITATIVE DETERMINATION OF QUINIDINE IN PLASMA [J].