Smart core-shell nanostructure with a mesoporous core and a stimuli-responsive nanoshell synthesized via surface reversible addition-fragmentation chain transfer polymerization

被引：64

作者：

Hong, Chun-Yan ^{[1
]}

Li, Xin ^{[1
]}

Pan, Cai-Yuan ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2008年 / 112卷 / 39期

关键词：

D O I：

10.1021/jp805028z

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A facile and versatile method to prepare mesoporous core-shell nanostructure with a stimuli-responsive nanoshell was reported. Reversible addition-fragmentation chain transfer (RAFT) functionalities were anchored to the mesoporous silica nanoparticle (MSN), and RAFT polymerization of N-isopropylacrylamide (NIPAAm) was subsequently conducted to graft thermo-sensitive PNIPAAm to the exterior surface of the MSN. The nanoshell undergoes reversible switches between solvated, incompact nanoshell and compact nanoshell upon changing the temperature of the solution, which makes this novel core-shell nanostructure highly attractive for controlled release of drugs, DNAs, and proteins.

引用

收藏

页码：15320 / 15324

页数：5

相关论文

共 28 条

[1] Control of molecular transport through stimuli-responsive ordered mesoporous materials [J].

Fu, Q ;

Rao, GVR ;

Ista, LK ;

Wu, Y ;

Andrzejewski, BP ;

Sklar, LA ;

Ward, TL ;

López, GP .

ADVANCED MATERIALS, 2003, 15 (15) :1262-+

[2] Thermoresponsive transport through ordered mesoporous silica/PNIPAAm copolymer membranes and microspheres [J].

Fu, Qiang ;

Rao, G. V. Rama ;

Ward, Timothy L. ;

Lu, Yunfeng ;

Lopez, Gabriel P. .

LANGMUIR, 2007, 23 (01) :170-174

[3] Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles [J].

Giri, S ;

Trewyn, BG ;

Stellmaker, MP ;

Lin, VSY .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (32) :5038-5044

[4] Grafting polymer nanoshell onto the exterior surface of mesoporous silica nanoparticles via surface reversible addition-fragmentation chain transfer polymerization [J].

Hong, Chun-Yan ;

Li, Xin ;

Pan, Cai-Yuan .

EUROPEAN POLYMER JOURNAL, 2007, 43 (10) :4114-4122

[5] Direct synthesis of biotinylated stimuli-responsive polymer and diblock copolymer by RAFT polymerization using biotinylated trithiocarbonate as RAFT agent [J].

Hong, CY ;

Pan, CY .

MACROMOLECULES, 2006, 39 (10) :3517-3524

[6] A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules [J].

Lai, CY ;

Trewyn, BG ;

Jeftinija, DM ;

Jeftinija, K ;

Xu, S ;

Jeftinija, S ;

Lin, VSY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (15) :4451-4459

[7] Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAFT agents [J].

Lai, JT ;

Filla, D ;

Shea, R .

MACROMOLECULES, 2002, 35 (18) :6754-6756

[8] Synthesis of well-defined polymer brushes grafted onto silica nanoparticles via surface reversible addition-fragmentation chain transfer polymerization [J].

Li, CZ ;

Benicewicz, BC .

MACROMOLECULES, 2005, 38 (14) :5929-5936

[9] Thermosensitive hairy hybrid nanoparticles synthesized by surface-initiated atom transfer radical polymerization [J].

Li, DJ ;

Jones, GL ;

Dunlap, JR ;

Hua, FJ ;

Zhao, B .

LANGMUIR, 2006, 22 (07) :3344-3351

[10] Environmentally responsive "Hairy" nanoparticles: Mixed homopolymer brushes on silica nanoparticles synthesized by living radical polymerization techniques [J].

Li, DJ ;

Sheng, X ;

Zhao, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (17) :6248-6256