RNAi-based nanomedicines for targeted personalized therapy

被引：137

作者：

Daka, Ala ^{[1
]}

Peer, Dan ^{[1
]}

机构：

[1] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 13期

基金：

以色列科学基金会;

关键词：

Short interfering RNA (siRNA); In vivo; Systemic delivery; Nanoparticles; Clinical trials; Personalized medicine; SMALL INTERFERING RNA; SIRNA DELIVERY-SYSTEM; LIPID-LIKE MATERIALS; SHORT HAIRPIN RNA; IN-VIVO DELIVERY; GENE-EXPRESSION; CARBON NANOTUBES; CHEMICAL-MODIFICATION; MACROMOLECULAR THERAPEUTICS; ANTISENSE OLIGONUCLEOTIDES;

D O I：

10.1016/j.addr.2012.08.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in order for RNAi to serve as an ideal personalized therapeutics and be clinically approved safe, specific, and potent strategies must be devised for efficient delivery of RNAi payloads to specific cell types, which despite the immense potential, remains a challenge. Through evaluating the recent reported studies in this field, we introduce the progress in designing targeted nano-scaled strategies that are anticipated to overcome the delivery drawbacks and along with the exciting "omics" discipline to personalize RNAi-based therapeutics. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1508 / 1521

页数：14

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