Long-term survival in primary plasma cell leukemia after therapy with VAD, autologous blood stem cell transplantation and interferon-alpha

被引：14

作者：

Panizo, C ^{[1
]}

Rifón, J ^{[1
]}

Rodríguez-Wilhelmi, P ^{[1
]}

Cuesta, B ^{[1
]}

Rocha, E ^{[1
]}

机构：

[1] Univ Navarra, Sch Med, Univ Navarra Clin, Dept Hematol, E-31008 Pamplona, Spain

来源：

ACTA HAEMATOLOGICA | 1999年 / 101卷 / 04期

关键词：

autologous blood stem cell transplantation; interferon-alpha; large granular lymphocytes; plasma cell leukemia;

D O I：

10.1159/000040952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary plasma cell leukemia (PCL) is a rare form of plasma cell neoplasm with a poor prognosis. Conventional melphalan-based treatments have been most disappointing. We report the case of a 62-year-otd man with a primary form of PCL treated with VAD combination achieving an objective response, and who received high-dose melphalan and autologous peripheral blood stem cell (PBSC) transplantation followed by interferon-alpha. During the remission time, lasting for 3 years, an infiltration by large granular lymphocytes (LGL) was noted in peripheral blood. However, when the number of LGL declined, a bone marrow relapse was observed. The treatment for PCL and the possible role of these LGL on tumor cell control after autologous PBSC transplantation are discussed.

引用

页码：193 / 196

页数：4

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