The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

被引：20

作者：

Bravo-San Pedro, Jose M. ^{[1
]}

Gomez-Sanchez, Ruben ^{[1
]}

Niso-Santano, Mireia ^{[1
]}

Pizarro-Estrella, Elisa ^{[1
]}

Aiastui-Pujana, Ana ^{[2
]}

Gorostidi, Ana ^{[2
]}

Climent, Vicente ^{[3
]}

Lopez de Maturana, Rakel ^{[4
]}

Sanchez-Pernaute, Rosario ^{[4
]}

Lopez de Munain, Adolfo ^{[5
]}

Fuentes, Jose M. ^{[1
]}

Gonzalez-Polo, Rosa A. ^{[1
]}

机构：

[1] Univ Extremadura, Dept Bioquim & Biol Mol & Genet, E Enfermeria & TO, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Caceres, Spain

[2] Ilundain Fdn, Hosp Donosti, Lab Neurogenet, San Sebastian, Spain

[3] Univ Extremadura, Fac Med, Dept Anat & Embriol Humana, Badajoz, Spain

[4] Fdn Inbiomed, Lab Celulas Madre & Neurorreparac, San Sebastian, Spain

[5] Hosp Donosti, Serv Neurol, Inst Biodonostia, Ctr Invest Biomed Red Enfermedades Neurodegenerat, San Sebastian, Spain

来源：

AUTOPHAGY | 2012年 / 8卷 / 10期

关键词：

autophagy; LRRK2; G2019S; MAPK1/3; Parkinson disease;

D O I：

10.4161/auto.21270

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway. © 2012 Landes Bioscience.

引用

页码：1537 / 1539

页数：3