Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBF alpha gene family

We cloned the human cDNA corresponding to the cDNA (PEBP2 alpha B-451) encoding the mouse polyoma virus enhancer-binding protein 2 alpha B-451, representing a major splice variant from acute myeloid leukemia gene 1 (AML1). Genomic DNA clones of AML1 were also isolated and the exon/intron structure was determined. Furthermore, we determined and compared the genomic structures of three mammalian Runt domain-containing genes, PEBP2 alpha A, AML1/PEBP2 alpha B and PEBP2 alpha C.