Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

被引:137
作者
Demangel, Caroline [1 ]
Stinear, Timothy P. [2 ]
Cole, Stewart T.
机构
[1] Inst Pasteur, UP Pathogenom Mycobacterienne Integree, F-75724 Paris, France
[2] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland
基金
英国医学研究理事会;
关键词
HOST IMMUNE-RESPONSE; RISK-FACTORS; PROTECTIVE EFFICACY; DNA VACCINE; CAUSATIVE AGENT; TOXIC MACROLIDE; WHOLE-BLOOD; MYCOLACTONE; INFECTION; DISEASE;
D O I
10.1038/nrmicro2077
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Buruli ulcer is an emerging human disease caused by infection with a slow-growing pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with immunomodulatory properties. The disease is associated with wetlands in certain tropical countries, and evidence for a role of insects in transmission of this pathogen is growing. Comparative genomic analysis has revealed that M. ulcerans arose from Mycobacterium marinum, a ubiquitous fast-growing aquatic species, by horizontal transfer of a virulence plasmid that carries a cluster of genes for mycolactone production, followed by reductive evolution. Here, the ecology, microbiology, evolutionary genomics and immunopathology of Buruli ulcer are reviewed.
引用
收藏
页码:50 / 60
页数:11
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