Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia

被引：37

作者：

Fariñas, I ^{[1
]}

Cano-Jaimez, M ^{[1
]}

Bellmunt, E ^{[1
]}

Soriano, M ^{[1
]}

机构：

[1] Univ Valencia, Dept Biol Celular, E-46100 Burjassot, Spain

来源：

BRAIN RESEARCH BULLETIN | 2002年 / 57卷 / 06期

关键词：

neurotrophic factors; mutant mice; dorsal root ganglia; precursors; cell death;

D O I：

10.1016/S0361-9230(01)00767-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurons and glia in spinal sensory ganglia derive from multipotent neural crest-derived stem cells. In contrast to neural progenitor cells in the central nervous system, neural crest progenitors coexist with differentiated sensory neurons all throughout the neurogenic period. Thus, developing sensory ganglia are advantageous for determining the possible influence of cell-cell interactions in the regulation of precursor proliferation and neurogenesis. Neurotrophins are important regulators of neuronal survival in the developing vertebrate nervous system and, in addition, they appear to influence precursor behavior in vitro. Studies in mice carrying mutations in neurotrophin genes provide a good system in which to analyze essential actions of these factors on the different developing neural populations. (C) 2002 Elsevier Science Inc.

引用

页码：809 / 816

页数：8

共 64 条

[1] Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation [J].