Novel o-phenylenediseleno bridged bis(β-cyclodextrin)s complexes with platinum(IV) and palladium(II) ions

The novel o-phenylenediseleno bridged bis(cyclodextrin)s and its complexes with platinum(IV) and palladium(II) ions have been synthesized and characterized by elemental analyses, H-1 NMR, infrared, and thermal analysis. Fluorescence spectrophotometric titrations have been performed in aqueous buffer solution (pH 7.20) at 25.0 degrees C to give the complex stability constants (K-s) and Gibbs free energy change (-Delta G degrees) for the 1:1 inclusion complexation of natural beta-cyclodextrin, the o-phenylenediseleno bridged bis(cyclodextrin)s 1 and its platinum(IV) complex 2 with 8-Anilino-1-naphthalenesulfonic Acid Ammonium Salt (ANS ammonium). The molecular inclusion ability of ANS ammonium by the three host compounds are discussed from the viewpoints of size/shape-fit concept and the multipoint recognition mechanism.