Serotonin type 3 receptor genes:: HTR3A, B, C, D, E

被引：68

作者：

Niesler, Beate ^{[1
]}

Kapeller, Johannes ^{[1
]}

Hammer, Christian ^{[1
]}

Rappold, Gudrun ^{[1
]}

机构：

[1] Univ Heidelberg, Dept Human Mol Genet, D-69120 Heidelberg, Germany

来源：

PHARMACOGENOMICS | 2008年 / 9卷 / 05期

关键词：

D O I：

10.2217/14622416.9.5.501

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 5-HT(3) receptor is a ligand-gated ion channel composed of five subunits. To date, five different human subunits are known, 5-HT(3A-E), which are encoded by the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E, respectively. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes seem to be involved in chemotherapy-induced nausea and vomiting (CINV), irritable bowel syndrome and psychiatric disorders. 5-HT3 receptor antagonists are established in the therapy of CINV and irritable bowel syndrome. HTR3A and HTR3B polymorphisms may also contribute to the etiology of psychiatric disorders and serve as predictors in CINV and in the medical treatment of psychiatric patients.

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页码：501 / 504

页数：4

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