Adaptive response induced by lipid peroxidation products in cell cultures

被引：59

作者：

Chen, ZH

Yoshida, Y

Saito, Y

Noguchi, N

Niki, E

机构：

[1] Natl Inst Adv Ind Sci & Technol, Human Stress Signal Res Ctr, Ikeda, Osaka 5638577, Japan

[2] Univ Tokyo, Adv Sci & Technol Res Ctr, Tokyo 1538904, Japan

[3] Doshisha Univ, Sci & Engn Res Inst, Kyoto 6100394, Japan

来源：

FEBS LETTERS | 2006年 / 580卷 / 02期

关键词：

lipid peroxidation products; adaptive response; oxidative stress; cytotoxicity;

D O I：

10.1016/j.febslet.2005.12.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The adaptive response induced by the lipid peroxidation products, such as phosphatidyleholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15-deoxy-Delta(12,14)-prostaglandin J(2), 4-hydroxynonenal (4-FINE), hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and cholesterol 5 beta,6 beta-epoxide, was investigated in this study. Although these products have been implicated in oxidative stress-related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6-hydroxydopamine. Moreover, 4-HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：479 / 483

页数：5

共 30 条

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