Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin

被引：56

作者：

Dong, Jing ^{[1
]}

Qiu, Jiazhang ^{[1
]}

Wang, Jianfeng ^{[1
]}

Li, Hongen ^{[1
]}

Dai, Xiaohan ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Xin ^{[2
]}

Tan, Wei ^{[1
]}

Niu, Xiaodi ^{[2
]}

Deng, Xuming ^{[1
]}

Zhao, Shuhua ^{[3
]}

机构：

[1] Jilin Univ, Coll Anim Sci & Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130041, Peoples R China

[2] Jilin Univ, Coll Quartermaster Technol, Changchun 130041, Peoples R China

[3] Jilin Univ, Hosp 2, Changchun 130041, Peoples R China

来源：

FEMS MICROBIOLOGY LETTERS | 2013年 / 338卷 / 02期

关键词：

apigenin; Staphylococcus aureus; a-hemolysin; pneumonia; IN-VITRO; EPITHELIAL-CELLS; RAT MODEL; VIRULENCE; TOXIN; EXPRESSION; LUNG; INFECTIONS; EVOLUTION; GROWTH;

D O I：

10.1111/1574-6968.12040

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Staphylococcus aureus is a common human pathogenic bacteria that can cause serious infections, including lethal staphylococcal pneumonia. The development of antimicrobial resistance has limited treatment options for this pathogen; consequently, novel antibiotics and strategies are urgently desired to combat these infections. In recent years, virulence factors secreted by pathogenic microorganisms have been developed as targets for drug discovery. Alpha-hemolysin, a pore-forming cytotoxin that is secreted by most S. aureus strains, is essential for the pathogenesis of S. aureus pneumonia. In this study, we report that apigenin, a compound extracted from parsley that has no antimicrobial activity vs. S. aureus in vitro, can remarkably decrease the production of a-hemolysin at low concentrations. When added to the A549 cells and S. aureus co-culture system, apigenin protected A549 cells from a-hemolysin-mediated injury. Furthermore, in vivo tests indicated that apigenin alleviated injury of the lung tissue and decreased cytokine levels in the bronchoalveolar lavage fluid in the mouse model of S. aureus pneumonia.

引用

页码：124 / 131

页数：8

共 31 条

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