The contradictory definitions of heterochromatin: transcription and silencing

被引：145

作者：

Huisinga, KL ^{[1
]}

Brower-Toland, B ^{[1
]}

Elgin, SCR ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

CHROMOSOMA | 2006年 / 115卷 / 02期

关键词：

D O I：

10.1007/s00412-006-0052-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic genomes are packaged in two general varieties of chromatin: gene-rich euchromatin and gene-poor heterochromatin. Each type of chromatin has been defined by the presence of distinct chromosomal proteins and posttranslational histone modifications. This review addresses recent findings that appear to blur the definitions of euchromatin and heterochromatin by pointing to the presence of typically heterochromatic modifications (including H3K9me) in euchromatin and typically euchromatic enzymes (including RNA polymerases) in heterochromatin. We discuss the implications of these new findings for the current definition of heterochromatin.

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页码：110 / 122

页数：13

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