Gene therapy for arthritis

被引：15

作者：

Traister, Russell S. ^{[1
]}

Hirsch, Raphael ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Div Rheumatol, Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

来源：

MODERN RHEUMATOLOGY | 2008年 / 18卷 / 01期

关键词：

Rheumatoid arthritis; Gene therapy; Gene transfer; Inflammation; Cytokines;

D O I：

10.1007/s10165-007-0017-9

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by short half-lives of the drugs and the requirement for repeated systemic administration. Utilizing gene transfer approaches for the treatment of arthritis may overcome some of the obstacles associated with current treatment strategies. The present review examines recent developments in gene therapy for arthritis. Delivery strategies, gene transfer vectors, candidate genes, and safety are also discussed.

引用

页码：2 / 14

页数：13

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