A versatile mechanism based reaction probe for the direct selection of biocatalysts

被引：23

作者：

Lo, LC

Lo, CHL

Janda, KD

Kassel, DB

Raushel, FM

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] Scripps Res Inst, DEPT MOL BIOL, LA JOLLA, CA 92037 USA

[3] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[4] COMBICHEM INC, SAN DIEGO, CA 92121 USA

[5] TEXAS A&M UNIV, DEPT CHEM, COLLEGE STN, TX 77843 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00379-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A mechanism based reaction probe was synthesized and shown to modify a bacterial phosphotriesterase; this strategy for generating a probe is general and should allow the isolation of a host of unique catalysts. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2117 / 2120

页数：4

共 11 条

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