The role of ROS and RNS in regulating life and death of blood monocytes

被引：129

作者：

Baran, CP ^{[1
]}

Zeigler, MM ^{[1
]}

Tridandapani, S ^{[1
]}

Marsh, CB ^{[1
]}

机构：

[1] Ohio State Univ, Div Pulm & Crit Care Med, Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43221 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2004年 / 10卷 / 08期

关键词：

D O I：

10.2174/1381612043452866

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The ability to target and accumulate monocytes and macrophages in areas of tissue inflammation plays an important role in innate and humoral immunity. However, when this process becomes uncontrolled, tissue injury and dysfunction may ensue. This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in regulating the molecular and biochemical pathways responsible for the regulation of the survival of human monocytes. We and others have found that ROS and RNS serve as important intracellular signaling molecules that influence cellular survival. Human monocytes are influenced by intracellular production of ROS and RNS, which affects both monocyte survival and death, depending on the form of nitric oxide presented to the cell. This review will address potential mechanisms by which ROS and RNS promote the survival of human monocytes and macrophages.

引用

页码：855 / 866

页数：12

共 119 条

[1]

INCREASED ABUNDANCE OF THE RECEPTOR-TYPE PROTEIN-TYROSINE-PHOSPHATASE LAR ACCOUNTS FOR THE ELEVATED INSULIN-RECEPTOR DEPHOSPHORYLATING ACTIVITY IN ADIPOSE-TISSUE OF OBESE HUMAN-SUBJECTS [J].