The gut microbiota regulates bone mass in mice

被引：551

作者：

Sjogren, Klara ^{[1
]}

Engdahl, Cecilia ^{[1
]}

Henning, Petra ^{[1
]}

Lerner, Ulf H. ^{[1
,2
]}

Tremaroli, Valentina ^{[3
]}

Lagerquist, Marie K. ^{[1
]}

Backhed, Fredrik ^{[3
]}

Ohlsson, Claes ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med, SE-41345 Gothenburg, Sweden

[2] Umea Univ, Dept Mol Periodontol, Umea, Sweden

[3] Univ Gothenburg, Sahlgrenska Acad, Ctr Cardiovasc & Metab Res, Wallenberg Lab, SE-41345 Gothenburg, Sweden

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2012年 / 27卷 / 06期

基金：

瑞典研究理事会;

关键词：

GERM FREE; OSTEOPOROSIS; OSTEOIMMUNOLOGY; SEROTONIN; BONE METABOLISM; TUMOR-NECROSIS-FACTOR; T-CELLS; FACTOR-ALPHA; SEROTONIN TRANSPORTER; RECEPTOR ACTIVATOR; GENE-EXPRESSION; DEFICIENT MICE; NUCLEAR-FACTOR; UP-REGULATION; KAPPA-B;

D O I：

10.1002/jbmr.1588

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV-R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV-R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast-mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. (C) 2012 American Society for Bone and Mineral Research.

引用

页码：1357 / 1367

页数：11

共 60 条

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