Biocompatibility testing of a new silver-impregnated catheter in vivo

The purpose of this investigation nas to compare the local effects of polyurethane (Tecothane(circle times)) and silicone tubes with or without silver impregnation in rats. Bacterial colonization or infection of the exit site and/or tunnel were documented and interpreted. All tubes were placed subcutaneously or percutaneously in the neck of 41 Sprague-Dawley rats and guided beneath the dorsal muscles into the peritoneal cavity: The incidence of bacterial abscesses along the implanted tubes,vase, evaluated daily After 90 days, or earlier if sepsis de, eloped, the animals were killed painlessly and,various organs and tissues from the entry site and the catheter tunnel examined histologically; In the group,where polyurethane tubes were placed percutaneously, there was no difference in the frequency of abscesses between silver-impregnated and non-impregnated tubes (5/6 with and 5/7 without silver), The only difference noted,vas in the group with percutaneously placed silicone tubes between those with and without silver. Abscesses only occurred in 2/4 animals in the silver, er group and in 5/5 animals in the control group. Histological examination showed no difference in either group between infectious and foreign body reactions. Silver, er particles in subcutaneous, muscle and peritoneal tissue could not be demonstrated.