Surfactant protein A and D expression in the porcine Eustachian tube

被引：48

作者：

Paananen, R

Glumoff, V

Hallman, N

机构：

[1] Univ Oulu, Bioctr, SF-90220 Oulu, Finland

[2] Univ Oulu, Dept Pediat, SF-90220 Oulu, Finland

来源：

FEBS LETTERS | 1999年 / 452卷 / 03期

基金：

芬兰科学院;

关键词：

surfactant protein A; surfactant protein D; Eustachian tube; collectin; gene expression;

D O I：

10.1016/S0014-5793(99)00602-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Surfactant proteins A and D are collectins which are considered to play an important role in the innate immunity of lungs, Our aim was to investigate whether surfactant protein A or D is expressed in the porcine Eustachian tube originating from the upper airways. Both surfactant proteins A and D were present in the epithelial cells of the Eustachian tube, as shown by strong immunostaining. Using RT-PCR and Northern hybridization, these collectins were detected in the Eustachian tube. The present study is the first report demonstrating surfactant protein gene expression in the Eustachian tube. Surfactant proteins A and D may be important in the antibody-independent protection of the middle ear. (C) 1999 Federation of European Biochemical Societies.

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收藏

页码：141 / 144

页数：4

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