Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives.

被引：10

作者：

Fancelli, D

Caccia, C

Fornaretto, MG

McArthur, R

Severino, D

Vaghi, F

Varasi, M

机构：

[1] Pharmacia and Upjohn, CNS Preclinical R and D, 20014 Nerviano, Milan, via per Pogliano

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/0960-894X(96)00002-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationships in a series of dihydrobenzofuran derivatives related structurally to the 5-HT3 antagonist and 5-ET(4) agonist ADR 932 (1) were investigated. Members of this series, such as (18) and (23), were found to be 5-HT4 agonists or partial agonists endowed with remarkably high affinity and selectivity.

引用

页码：263 / 266

页数：4

共 22 条

[1]

ANDREWS P L R, 1992, European Journal of Cancer, V28A, pS2, DOI 10.1016/0959-8049(92)90628-F

[2]

ARRIGONI C, 1992, PHARMACEUT RES, V26, P319

[3]

BAXTER GS, 1991, N-S ARCH PHARMACOL, V343, P439

[4] QUATERNIZED RENZAPRIDE AS A POTENT AND SELECTIVE 5-HT4 RECEPTOR AGONIST [J].