Pneumocystis jiroveci Pneumonia in Patients with Non-Hodgkin's Lymphoma Receiving Chemotherapy Containing Rituximab

被引：17

作者：

Chang, Hung ^{[1
,4
]}

Yeh, Huei-Chung ^{[2
]}

Su, Yung-Cheng

Lee, Ming-Hsun ^{[3
,4
]}

机构：

[1] Chang Gung Mem Hosp, Dept Internal Med, Div Hematol Oncol, Tao Yuan 333, Taiwan

[2] Chang Gung Mem Hosp, Dept Gastroenterol & Hepatol, Tao Yuan 333, Taiwan

[3] Chang Gung Mem Hosp, Dept Internal Med, Div Infect Dis, Tao Yuan 333, Taiwan

[4] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2008年 / 71卷 / 11期

关键词：

febrile neutropenia; lymphoma; opportunistic infection; Pneumocystis jiroveci; rituximab;

D O I：

10.1016/S1726-4901(08)70173-4

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Rituximab enhances treatment efficacy of B-lineage lymphoma by targeting CD20(+) B-cells. Such target therapies may compromise the immune system and render patients susceptible to opportunistic infections. We report 2 cases of lymphoma complicated with Pneumocystis jiroveci (previously known as P carinii) pneumonia (PCP) while being treated with rituximab-containing chemotherapy regimens. In both cases, PCP developed during the neutropenic period. With timely diagnosis and proper management, both were treated successfully. We searched the literature and found that such opportunistic infection occurred only infrequently in lymphoma patients, and it has not been reported in the large-scale clinical trials of rituximab. Such cases demonstrate the importance of taking PCP into diagnostic consideration in lymphoma patients receiving similar therapies. [J Chin Med Assoc 2008;71(11):579-582]

引用

页码：579 / 582

页数：4

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