A synthesis and proper-ties of new 4,4-difluoro-3a,4a-diaza-s-indacene (BODIPY)-labeled lipids

被引：34

作者：

Boldyrev, IA ^{[1
]}

Molotkovsky, JG ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2006年 / 32卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

BODIPY; fluorescent lipid probes; synthesis;

D O I：

10.1134/S1068162006010080

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of fluorescently labeled fatty acids of various chain lengths with 4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene-8-Y1 (Me-4-BODIPY-8) residue in the omega-position were synthesized. These acids were used to prepare new fluorescently labeled phosphatidylcholines, sphincyomyelin, and galactosyl ceramide. The symmetry of the Me-4-BODIPY-8-fluorophore suggests that, in most bilayer membrane systems, this fluorophore would be embedded into the bilayer.

引用

页码：78 / 83

页数：6

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