Molecular pharmacological basis of the YiSui ShenXu Granule in β-thalassemia therapy

被引：12

作者：

Zhang, Chong ^{[1
]}

Wu, Zhi-Kui ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Guanganmen Hosp, Mol Biol Lab, Beijing 100053, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 120卷 / 03期

基金：

中国国家自然科学基金;

关键词：

YiSui ShenXu Granule; Molecular pharmacological basis; beta-Thalassemia; K562; cell;

D O I：

10.1016/j.jep.2008.09.024

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Objectives: To study the molecular pharmacological basis of the YiSui ShenXu Granule, a complex prescription of the Chinese traditional medicine used to treat beta-thalassemia. Methods: Real-time quantitative PCR method had been applied to analyze the genes expression: gamma-globin, Ckit, EpoR, Spi, FKLF, GATA1 and GATA2 in K562 cell treated and untreated with this complex prescription and its each single herbal medicine. Results: The results showed that this complex prescription increased the gamma-globin, EpoR, Spi and FKLF expression and decreased the Ckit, GATA1 and GATA2 expression. And all single herbal medicines of this complex prescription could change some of those gene expressions, but not the same as the complex prescription. Even that, this study results indicated that the YiSui ShenXu Granule has its molecular pharmacological basis in treating beta-thalassemia. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：437 / 441

页数：5

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