Inhibitory effect of Total Flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons

被引：21

作者：

Cheng, Xin-Ping

Qin, Song

Dong, Liu-Yi

Zhou, Jiang-Ning

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol & Biophys, Hefei 230027, Anhui, Peoples R China

[3] Anhui Med Univ, Dept Pharmacol, Hefei 230032, Anhui, Peoples R China

来源：

NEUROSCIENCE RESEARCH | 2006年 / 55卷 / 02期

关键词：

Total Flavone of Abelmoschus manihot L. Medic (TFA); NMDA receptor; whole-cell patch-clamp technique; hippocampal neurons;

D O I：

10.1016/j.neures.2006.02.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The modulatory effect of Total Flavone of Abelmoschus manihot L. Medic (TFA) on NMDA-activated current (I-NMDA) was investigated in cultured rat hippocampal neurons using the whole-cell patch-clamp technique. TFA rapidly and reversibly inhibited the INMDA in a concentration-dependent manner. Furthermore, TFA non-competitively inhibited the I-NMDA by enhancement of the NMDA receptor desensitization. In addition, intracellular application of TFA did not alter the TFA inhibition Of INMDA. These results suggest that the inhibition of the NMDA receptor response by TFA could be one of the mechanisms for TFA-mediated neuroprotective actions. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：142 / 145

页数：4

共 14 条

[1] OXIDATIVE STRESS, GLUTAMATE, AND NEURODEGENERATIVE DISORDERS [J].