Importance of the mutation of amino acid 200 of the isotype 1 β-tubulin gene in the benzimidazole resistance of the small ruminant parasite Teladorsagia circumcincta

被引：99

作者：

Elard, L

Humbert, JF

机构：

[1] INRA, Stn Hydrobiol Lacustre, F-74203 Thonon, France

[2] INRA, Ctr Tours, Pathol Aviaire & Parasitol Stn, F-37380 Nouzilly, France

来源：

PARASITOLOGY RESEARCH | 1999年 / 85卷 / 06期

关键词：

D O I：

10.1007/s004360050577

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In this work we demonstrated that the acquisition of benzimidazole (BZ) resistance in the small-ruminant parasite Teladorsagia circumcincta is linked to the selection of individuals that are characterized by a tyrosine (Tyr) at amino acid 200 of their isotype 1 beta-tubulin gene. This mutation appears to be recessive, since only homozygous mutant (Tyr/Tyr) individuals survived after BZ treatment of two resistant populations in which the three genotypes (rr, rs, ss) were initially present. In comparison with natural BZ-susceptible populations, a decrease in the restriction polymorphism (RFLP) of the isotype 1 P-tubulin gene was observed in natural resistant populations. It seems that this decrease in P-tubulin polymorphism results from the selection of homozygous mutant individuals.

引用

页码：452 / 456

页数：5

共 18 条

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