What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

被引：101

作者：

Pelletier, J-P ^{[1
]}

Cooper, C. ^{[2
,3
]}

Peterfy, C. ^{[4
]}

Reginster, J-Y ^{[5
]}

Brandi, M-L ^{[6
]}

Bruyere, O. ^{[5
]}

Chapurlat, R. ^{[7
,8
]}

Cicuttini, Flavia M. ^{[9
]}

Conaghan, P. G. ^{[10
,11
]}

Doherty, M. ^{[12
]}

Genant, H. ^{[13
,14
,15
,16
]}

Giacovelli, G. ^{[17
]}

Hochberg, M. C. ^{[18
,19
]}

Hunter, D. J. ^{[20
,21
]}

Kanis, J. A. ^{[22
]}

Kloppenburg, M. ^{[23
]}

Laredo, J-D ^{[24
,25
]}

McAlindon, T. ^{[26
]}

Nevitt, M. ^{[27
]}

Raynauld, J-P ^{[1
]}

Rizzoli, R. ^{[28
,29
]}

Zilkens, C. ^{[30
]}

Roemer, F. W. ^{[31
,32
]}

Martel-Pelletier, J. ^{[1
]}

Guermazi, A. ^{[32
]}

机构：

[1] Univ Montreal Hosp Res Ctr CRCHUM, Notre Dame Hosp, Osteoarthrit Res Unit, Montreal, PQ H2L 4M1, Canada

[2] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[3] Univ Oxford, NIHR Musculoskeletal Biomed Res Unit, Oxford, England

[4] Spire Sci LLC, San Francisco, CA USA

[5] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium

[6] Univ Florence, Dept Internal Med, Bone Metab Unit, Florence, Italy

[7] INSERM, UMR 1033, Serv Rhumatol & Pathol Osseuse, F-69008 Lyon, France

[8] Univ Lyon, Hop Edouard Herriot, Lyon, France

[9] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia

[10] Univ Leeds, Div Musculoskeletal Dis, Leeds, W Yorkshire, England

[11] NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

[12] Univ Nottingham, City Hosp Nottingham, Nottingham NG7 2RD, England

[13] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

[14] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[15] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA USA

[16] Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA USA

[17] Rottapharm Madaus Grp, Clin Res Unit, Monza, Italy

[18] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[19] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

[20] Royal N Shore Hosp, Dept Rheumatol, Sydney, NSW, Australia

[21] Univ Sydney, Northern Clin Sch, Sydney, NSW 2006, Australia

[22] Univ Sheffield, Sch Med, WHO Collaborating Ctr Metab Bone Dis, Sheffield, S Yorkshire, England

[23] Leiden Univ, Med Ctr, Dept Rheumatol, Leiden, Netherlands

[24] Lariboisiere Hosp, AP HP, Dept Radiol, Bone & Joint Imaging Unit, Paris, France

[25] Univ Paris Diderot, Paris, France

[26] Tufts Med Ctr, Div Rheumatol, Boston, MA USA

[27] Univ Calif San Francisco, Dept Epidemiol & Biostat, OAI Coordinating Ctr, San Francisco, CA 94143 USA

[28] Univ Hosp Geneva, Div Bone Dis, Geneva, Switzerland

[29] Fac Med, Geneva, Switzerland

[30] Univ Dusseldorf, Dept Orthopaed Surg, Fac Med, D-40225 Dusseldorf, Germany

[31] Univ Erlangen Nurnberg, Dept Radiol, D-91054 Erlangen, Germany

[32] Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2013年 / 72卷 / 10期

关键词：

Knee Osteoarthritis; Magnetic Resonance Imaging; Outcomes research; BONE-MARROW LESIONS; CARTILAGE VOLUME LOSS; MULTICENTER CLINICAL-TRIAL; JOINT REPLACEMENT; RISK-FACTORS; SEMIQUANTITATIVE ASSESSMENT; LONGITUDINAL ASSESSMENT; DISEASE PROGRESSION; ARTICULAR-CARTILAGE; QUANTITATIVE MRI;

D O I：

10.1136/annrheumdis-2013-203631

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.

引用

页码：1594 / 1604

页数：11

共 88 条

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