Timeline - Jurkat T cells and development of the T-cell receptor signalling paradigm

被引：442

作者：

Abraham, RT

Weiss, A

机构：

[1] Burnham Inst, Program Signal Transduct Res, La Jolla, CA 92037 USA

[2] Univ Calif San Francisco, Rosalind Russell Ctr Med Res Arthrit, Howard Hughes Med Inst, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Rosalind Russell Ctr Med Res Arthrit, Howard Hughes Med Inst, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 04期

关键词：

D O I：

10.1038/nri1330

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Twenty years of investigation have yielded a detailed view of the signalling machinery engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling came from studies carried out with transformed T-cell lines. Perhaps the best known of these model systems is the Jurkat leukaemic T-cell line, and here we review some of the key advances in the field of TCR signalling that were made with Jurkat T cells as the host.

引用

页码：301 / 308

页数：8

共 89 条

[1]

Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways [J].