Asthma genetics

被引：66

作者：

Cookson, WOC ^{[1
]}

机构：

[1] Univ Oxford, Dept Human Genet, Oxford, England

来源：

CHEST | 2002年 / 121卷 / 03期

关键词：

D O I：

10.1378/chest.121.3_suppl.7S-a

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Asthma is the most common chronic childhood disease in developed nations and is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. identifying the genes underlying asthma offers a means of better understanding its pathogenesis, with the promise of improving preventive strategies, diagnostic tools, and therapies. A number of chromosomal regions containing genes influencing asthma and atopy have been identified consistently by different groups, and a role for several candidate genes has been established.

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页码：7S / 13S

页数：7

相关论文

共 108 条

[1]

Akolkar PN, 1997, AM J GASTROENTEROL, V92, P2241

[2] A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E [J].

Baldini, M ;

Lohman, IC ;

Halonen, M ;

Erickson, RP ;

Holt, PG ;

Martinez, FD .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (05) :976-983

[3] Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations [J].

Barnes, KC ;

Neely, JD ;

Duffy, DL ;

Freidhoff, LR ;

Breazeale, DR ;

Schou, C ;

Naidu, RP ;

Levett, PN ;

Renault, B ;

Kucherlapati, R ;

Iozzino, S ;

Ehrlich, E ;

Beaty, TH ;

Marsh, DG .

GENOMICS, 1996, 37 (01) :41-50

[4] Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy [J].

Barnes, KC ;

Freidhoff, LR ;

Nickel, R ;

Chiu, YF ;

Juo, SH ;

Hizawa, N ;

Naidu, RP ;

Ehrlich, E ;

Duffy, DL ;

Schou, C ;

Levett, PN ;

Marsh, DG ;

Beaty, TH .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (02) :485-491

[5] Human type 1 diabetes and the insulin gene: Principles of mapping polygenes [J].

Bennett, ST ;

Todd, JA .

ANNUAL REVIEW OF GENETICS, 1996, 30 :343-370

[6]

Beyer K, 1998, J ALLERGY CLIN IMMUN, V101, pS152

[7] Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells [J].

Bix, M ;

Locksley, RM .

SCIENCE, 1998, 281 (5381) :1352-1354

[8] Prevalence of tumor necrosis factor-α and angiotensin converting enzyme polymorphisms in mild moderate and fatal/near-fatal asthma [J].

Chagani, T ;

Paré, PD ;

Zhu, S ;

Weir, TD ;

Bai, TR ;

Behbehani, NA ;

Fitzgerald, JM ;

Sandford, AJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (01) :278-282

[9] Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping [J].

Chavanas, S ;

Garner, C ;

Bodemer, C ;

Ali, M ;

Hamel-Teillac, D ;

Wilkinson, J ;

Bonafé, JL ;

Paradisi, M ;

Kelsell, DP ;

Ansai, S ;

Mitsuhashi, Y ;

Larrègue, M ;

Leigh, IM ;

Harper, JI ;

Taïeb, A ;

de Prost, Y ;

Cardon, LR ;

Hovnanian, A .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (03) :914-921

[10] Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome [J].

Chavanas, S ;

Bodemer, C ;

Rochat, A ;

Hamel-Teillac, D ;

Ali, M ;

Irvine, AD ;

Bonafé, JL ;

Wilkinson, J ;

Taïeb, A ;

Barrandon, Y ;

Harper, JI ;

de Prost, Y ;

Hovnanian, A .

NATURE GENETICS, 2000, 25 (02) :141-142

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