Axonal transcription factors signal retrogradely in lesioned peripheral nerve

被引：243

作者：

Ben-Yaakov, Keren ^{[1
]}

Dagan, Shachar Y. ^{[1
]}

Segal-Ruder, Yael ^{[1
]}

Shalem, Ophir ^{[2
]}

Vuppalanchi, Deepika ^{[3
]}

Willis, Dianna E. ^{[4
]}

Yudin, Dmitry ^{[1
]}

Rishal, Ida ^{[1
]}

Rother, Franziska ^{[5
]}

Bader, Michael ^{[5
]}

Blesch, Armin ^{[6
,7
]}

Pilpel, Yitzhak ^{[2
]}

Twiss, Jeffery L. ^{[8
]}

Fainzilber, Mike ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[3] IU Sch Med, Stark Neurosci Res Inst, Indianapolis, IN USA

[4] Cornell Univ, Weill Med Coll, Burke Med Res Inst, Dept Neurol & Neurosci, White Plains, NY USA

[5] Max Delbruck Ctr Mol Med, Berlin, Germany

[6] Univ Heidelberg Hosp, Spinal Cord Injury Ctr, Heidelberg, Germany

[7] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[8] Drexel Univ, Dept Biol, Philadelphia, PA 19104 USA

来源：

EMBO JOURNAL | 2012年 / 31卷 / 06期

基金：

美国国家科学基金会; 以色列科学基金会;

关键词：

axonal transport; dynein; importin; neuronal injury; STAT; MESSENGER-RNA; C-JUN; PROTEIN-SYNTHESIS; STAT3; ACTIVATION; ADULT-RAT; REGENERATION; INJURY; AXOTOMY; NEURONS; TRANSPORT;

D O I：

10.1038/emboj.2011.494

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha 5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus. The EMBO Journal (2012) 31, 1350-1363. doi: 10.1038/emboj. 2011.494; Published online 13 January 2012

引用

页码：1350 / 1363

页数：14

共 75 条

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