Polydatin protects learning and memory impairments in a rat model of vascular dementia

被引：77

作者：

Li, Run-Ping ^{[2
]}

Wang, Zhong-Zhuang ^{[3
]}

Sun, Ming-Xue ^{[1
]}

Hou, Xiao-Li ^{[1
]}

Sun, Yawen ^{[2
]}

Deng, Zhao-Fang ^{[2
]}

Xiao, Kai ^{[1
]}

机构：

[1] Second Mil Med Univ, Lab Toxicol & Pharmacol, Fac Naval Med, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Fac Naval Med, Dept Div Med, Shanghai 200433, Peoples R China

[3] Changhai Hosp, Dept Pharm, Shanghai 200433, Peoples R China

来源：

PHYTOMEDICINE | 2012年 / 19卷 / 8-9期

基金：

中国国家自然科学基金;

关键词：

Polydatin; Polygonum cuspidatum; Vascular dementia; Anti-oxidant activity; CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY; 4-VESSEL OCCLUSION; BRAIN; NEUROPROTECTION; INHIBITION; DEFICITS; DEATH;

D O I：

10.1016/j.phymed.2012.03.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Polydatin is one of the most common encountered stilbenes of nature and a key component of the Chinese herb Polygonum cuspidatum. This study is to investigate the effects of polydatin on learning and memory impairments induced by chronic cerebral hypoperfusion in rats, as well as the potential mechanism. Both common carotid arteries and both vertebral arteries occlusion (four-vessel occlusion, 4-V0) induced severe cognitive deficits tested by water maze task, along with oxidative stress in hippocampus. Oral administration of polydatin for 30 days markedly attenuated cognitive deficits compared with the control (p < 0.05). Biochemical determination revealed that polydatin decreased the production of malondialdehyde (MDA) and significantly increased the activities of superoxide dismutase (SOD) and catalase (CAT). Additionally, polydatin effectively alleviated the injuries of cultured neurons induced by oxygen-glucose deprivation (OGD). These results suggest that polydatin exhibit therapeutic potential for vascular dementia, which is most likely related, at least in part, to its anti-oxidant activity and the direct protection of neurons. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：677 / 681

页数：5

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