Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

被引：626

作者：

Mold, Jeff E. ^{[1
,2
]}

Michaelsson, Jakob ^{[3
]}

Burt, Trevor D. ^{[1
,4
]}

Muench, Marcus O. ^{[5
,6
]}

Beckerman, Karen P. ^{[7
]}

Busch, Michael P. ^{[5
,6
]}

Lee, Tzong-Hae ^{[5
,6
]}

Nixon, Douglas F. ^{[1
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 USA

[2] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA

[3] Karolinska Univ Hosp, Karolinska Inst, Ctr Infect Med, Dept Med, S-14186 Huddinge, Sweden

[4] Univ Calif San Francisco, Dept Pediat, Div Neonatol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94118 USA

[6] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA

[7] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA

来源：

SCIENCE | 2008年 / 322卷 / 5907期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1126/science.1164511

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self- reactive cells. Here, we show that the human fetal immune system takes advantage of an additional mechanism: the generation of regulatory T cells ( T-regs) that suppress fetal immune responses. We find that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of CD4+CD25(high)FoxP3+ T-regs that suppress fetal antimaternal immunity and persist at least until early adulthood. These findings reveal a form of antigen- specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth.

引用

页码：1562 / 1565

页数：4

共 24 条

[1]

Microchimerism - An investigative frontier in autoimmunity and transplantation [J].