Role of regulatory T cells in human diseases

被引:240
作者
Chatila, TA [1 ]
机构
[1] Univ Calif Los Angeles, Div Rheumatol Allergy & Immunol, Dept Pediat, David Geffen Sch Med, Los Angeles, CA 90095 USA
关键词
regulatory T cells; Foxp3; dysregulation polyendocrinopathy enteropathy-X linked; X-linked autoimmunity-allergic dysregulation; allergy; autoimmunity; lymphoproliferation; immunotherapy; IgE;
D O I
10.1016/j.jaci.2005.08.047
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The discovery of regulatory T lymphocytes (Treg) that are actively involved in maintaining immune tolerance has led to new insights into mechanisms of tolerance breakdown in human diseases, including those resulting from allergic, autoimmune, or infectious causes. Congenital deficiency of CD4(+)CD25(+) Treg cells caused by loss-of-function mutations in the gene encoding Foxp3 triggers a syndrome of lymphoproliferation and myeloproliferation, autoimmunity, and allergic dysregulation, whereas deficient allergen-specific Treg cell responses have been associated with a number of allergic and autoimmune disorders. Tolerization to allergens and autoantigens is associated with augmentation of Treg cell numbers and suppressive function, suggesting the manipulation of Treg cell activity as a potential strategy for future therapeutic interventions in allergic and autoimmune diseases.
引用
收藏
页码:949 / 959
页数:11
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共 123 条
  • [1] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Akdis, M
    Verhagen, J
    Taylor, A
    Karamloo, F
    Karagiannidis, C
    Crameri, R
    Thunberg, S
    Deniz, G
    Valenta, R
    Fiebig, H
    Kegel, C
    Disch, R
    Schmidt-Weber, CB
    Blaser, K
    Akdis, CA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) : 1567 - 1575
  • [2] Toll-like receptors: critical proteins linking innate and acquired immunity
    Akira, S
    Takeda, K
    Kaisho, T
    [J]. NATURE IMMUNOLOGY, 2001, 2 (08) : 675 - 680
  • [3] In vivo instruction of suppressor commitment in naive T cells
    Apostolou, I
    von Boehmer, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (10) : 1401 - 1408
  • [4] Origin of regulatory T cells with known specificity for antigen
    Apostolou, I
    Sarukhan, A
    Klein, L
    von Boehmer, H
    [J]. NATURE IMMUNOLOGY, 2002, 3 (08) : 756 - 763
  • [5] Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease
    Arkwright, PD
    David, TJ
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (03) : 531 - 534
  • [6] Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    Asano, M
    Toda, M
    Sakaguchi, N
    Sakaguchi, S
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) : 387 - 396
  • [7] HIGH-LEVELS OF INTERLEUKIN-10 PRODUCTION IN-VIVO ARE ASSOCIATED WITH TOLERANCE IN SCID PATIENTS TRANSPLANTED WITH HLA MISMATCHED HEMATOPOIETIC STEM-CELLS
    BACCHETTA, R
    BIGLER, M
    TOURAINE, JL
    PARKMAN, R
    TOVO, PA
    ABRAMS, J
    MALEFYT, RD
    DEVRIES, JE
    RONCAROLO, MG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) : 493 - 502
  • [8] Suppressor T cells in human diseases
    Baecher-Allan, C
    Hafler, DA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (03) : 273 - 276
  • [9] Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    Balandina, A
    Lécart, S
    Dartevelle, P
    Saoudi, A
    Berrih-Aknin, S
    [J]. BLOOD, 2005, 105 (02) : 735 - 741
  • [10] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Barrat, FJ
    Cua, DJ
    Boonstra, A
    Richards, DF
    Crain, C
    Savelkoul, HF
    de Waal-Malefyt, R
    Coffman, RL
    Hawrylowicz, CM
    O'Garra, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) : 603 - 616