Enzymatic introduction of N-heterocyclic and As-containing head groups into glycerophospholipids

被引：15

作者：

Hirche, F ^{[1
]}

Schierhorn, A ^{[1
]}

Scherer, G ^{[1
]}

UlbrichHofmann, R ^{[1
]}

机构：

[1] UNIV HALLE WITTENBERG,DEPT BIOCHEM BIOTECHNOL,D-06099 HALLE,GERMANY

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)00082-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of six new glycerophospholipids with choline-analogous head groups by enzymatic transphosphatidylation with phospholipase D is described. Starting from 1,2-dioleoyl-sn-glycero-3-phosphocholine primary or secondary N-heterocyclic alcohols and (2-hydroxyethyl) trimethylarsonium were substituted for choline in two-phase systems. (C) 1997 Elsevier Science Ltd.

引用

页码：1369 / 1370

页数：2

共 7 条

[1] PHOSPHOLIPIDS AS FUNCTIONAL CONSTITUENTS OF BIOMEMBRANES [J].

EIBL, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (04) :257-271

[2]

Eibl H, 1981, Methods Enzymol, V72, P632

[3]

Heller M, 1978, Adv Lipid Res, V16, P267

[4]

HIRCHE F, IN PRESS ENZ MICROB

[5] PLANT LIPASES AND THEIR APPLICATION IN LIPID BIOTRANSFORMATIONS [J].

MUKHERJEE, KD .

PROGRESS IN LIPID RESEARCH, 1994, 33 (1-2) :165-174

[6] STRATEGIES FOR THE SYNTHESIS OF GLYCEROPHOSPHOLIPIDS [J].

PALTAUF, F ;

HERMETTER, A .

PROGRESS IN LIPID RESEARCH, 1994, 33 (03) :239-328

[7] A FACILE ONE-STEP SYNTHESIS OF 5'-PHOSPHATIDYLNUCLEOSIDES BY AN ENZYMATIC 2-PHASE REACTION [J].

SHUTO, S ;

UEDA, S ;

IMAMURA, S ;

FUKUKAWA, K ;

MATSUDA, A ;

UEDA, T .

TETRAHEDRON LETTERS, 1987, 28 (02) :199-202

← 1 →