Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3)

被引：48

作者：

Choi, Sung-Kyu

Oh, Hyun-Mi

Lee, Su-Kyung

Jeong, Dae Gwin

Ryu, Seong Eon

Son, Kwang-Hee

Han, Dong Cho

Sung, Nack-Do

Baek, Nam-In

Kwon, Byoung-Mog

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[2] Chungnam Natl Univ, Div Appl Biol & Chem, Taejon 305764, South Korea

[3] Kyung Hee Univ, Grad Sch Biotechnol, Kyonggi Do 449701, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 04期

关键词：

biflavonoids; PRL-3; Taxus cuspidata; ginkgetin; sciadopitysin; metastasis;

D O I：

10.1080/14786410500463312

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 mu M, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.

引用

页码：341 / 346

页数：6

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