Safety and immunogenicity of two octavalent pneumococcal conjugate vaccines in American Indian infants

被引：4

作者：

Eick, A ^{[1
]}

Croll, J ^{[1
]}

Weatherholtz, R ^{[1
]}

Croll, L ^{[1
]}

Santosham, M ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Amer Indian Hlth, Baltimore, MD 21205 USA

来源：

VACCINE | 2004年 / 22卷 / 9-10期

关键词：

pneumococcal conjugate vaccine; immunogenicity; American Indian;

D O I：

10.1016/j.vaccine.2003.09.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the safety and immunogenicity of two octavalent pneumococcal polysaccharide vaccines (serotypes 3, 4, 6B, 9V, 14, 18C, 19F, and 23F) conjugated to either diphtheria toxoid (PncD) or tetanus protein (PncT) among White Mountain Apache and Gila River Indian Community infants. This was a prospective, non-randomized, open label, comparative pilot study of PncD and PncT. Since this was a pilot study, a small sample size of 60 infants was enrolled. Enrolled healthy infants received either PncD or PncT at 2, 4, and 6 months of age. Antibody concentrations were measured by enzyme-immunoassay (EIA) prior to each dose and 1 month after the last dose. Local reaction rates were similar between PncD and PncT groups. The geometric mean concentrations (GMCs) were significantly higher for PncD than PncT for serotype 3 whereas GMCs were significantly higher for PncT for serotype 4. For this pilot study, both vaccines appeared to be safe and immunogenic in this group of American Indian infants. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：1260 / 1264

页数：5

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