A soluble polymer-bound approach to the sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a [(DHQD)(2)PHAL-PEG-OMe] ligand

被引：88

作者：

Han, HS

Janda, KD

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)00129-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a soluble polymer-bound (DHQD)(2)PHAL ligand 1 and its successful application in the catalytic asymmetric dihydroxylation reaction are described. The results highlight that the soluble polymer-bound ligand approach offers all the benefits associated with insoluble supports but with the key advantages of increased reactivity and enantioselectivity inherent with solution-phase methodology. (C) 1997 Elsevier Science Ltd.

引用

页码：1527 / 1530

页数：4

共 22 条

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