Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections

被引：58

作者：

Amaral, Leonard ^{[1
]}

Viveiros, Miguel ^{[1
]}

机构：

[1] Univ Nova Lisboa, Inst Hyg & Trop Med, P-1049008 Lisbon, Portugal

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 39卷 / 05期

关键词：

MDR-TB; XDR-TB; TDR-TB; Thioridazine; Cure; Enhanced intracellular killing; Inhibition of efflux pumps; IN-VITRO ACTIVITY; EFFLUX PUMPS; POTENTIAL USE; XDR-TB; CALCIUM; PHENOTHIAZINES; CALMODULIN; THERAPY; INHIBITORS; MANAGEMENT;

D O I：

10.1016/j.ijantimicag.2012.01.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure. This is due to the fact that TDZ enhances the killing of intracellular M. tuberculosis by non-killing macrophages, inhibits the genetic expression of efflux pumps of M. tuberculosis that extrude antibiotics prior to reaching their intended targets, and inhibits the activity of existing efflux pumps that contribute to the multidrug-resistant phenotype of M. tuberculosis. The combination of these effects of TDZ probably contributes to the successful recent cures of XDR-TB cases when the phenothiazine TDZ is used in combination with antibiotics to which the patient with XDR-TB was initially unresponsive. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：376 / 380

页数：5

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