Alterations in protein kinase A and different protein kinase C isoforms in the heart during morphine withdrawal

被引：10

作者：

Cerezo, M ^{[1
]}

Milanés, MV ^{[1
]}

Laorden, ML ^{[1
]}

机构：

[1] Univ Murcia, Sch Med, Equip Cellular & Mol Pharmacol, Murcia, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 522卷 / 1-3期

关键词：

heart; morphine withdrawal; protein kinase A; protein kinase C;

D O I：

10.1016/j.ejphar.2005.08.025

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The present study was designed to investigate the possible changes of protein kinase A (PKA) and different isoforms of protein kinase C (PKC): PKC alpha, PKC delta and PKC zeta after naloxone induced morphine withdrawal in the heart. Male rats were implanted with placebo (naive) or morphine (tolerant/dependent) pellets for 7 days. On day 8 rats received saline s.c. or naloxone (5 mg/kg s.c.). The protein levels of PKA, PKC 8 and PKC were significantly up-regulated in the heart from morphine withdrawal rats. By contrast, morphine withdrawal induced down-regulation of PKC a. These results suggest that both PKA and PKC may be involved in the cardiac adaptive changes observed during morphine withdrawal. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：9 / 19

页数：11

共 34 条

[1]

Involvement of 3′,5′-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups [J].