Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs

被引：39

作者：

Yun, Nadezhda E. ^{[1
]}

Linde, Nathaniel S. ^{[1
]}

Dziuba, Natallia ^{[1
]}

Zacks, Michele A. ^{[1
]}

Smith, Jeanon N. ^{[1
]}

Smith, Jennifer K. ^{[1
]}

Aronson, Judy F. ^{[1
]}

Chumakova, Olga V. ^{[1
]}

Lander, Heather M. ^{[1
]}

Peters, Clarence J. ^{[1
]}

Paessler, Slobodan ^{[1
]}

机构：

[1] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Inst Human Infect & Immun, Dept Pathol, Galveston, TX 77555 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 79卷 / 02期

关键词：

D O I：

10.4269/ajtmh.2008.79.275

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the virulence of two Junin virus strains in inbred and outbred guinea pigs with the aim of characterizing this animal model better for future vaccine/antiviral efficacy studies. Our data indicate that this passage of the XJ strain is attenuated in guinea pigs. In contrast, the Romero strain is highly virulent in Strain 13 as well as in Hartley guinea pigs, resulting in systemic infection, thrombocytopenia, elevated apartate aminotransferase levels, and ultimately, uniformly lethal disease. We detected viral antigen in formalin-fixed, paraffin-embedded tissues. Thus, both guinea pig strains are useful animal models for lethal Junin virus (Romero strain) infection and potentially can be used for preclinical trials in vaccine or antiviral drug development.

引用

页码：275 / 282

页数：8

共 40 条

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