Estrogen receptor α gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts

被引：83

作者：

Shearman, AM

Cooper, JA

Kotwinski, PJ

Miller, GJ

Humphries, SE

Ardlie, KG

Jordan, B

Irenze, K

Lunetta, KL

Schuit, SCE

Uitterlinden, AG

Pols, HAP

Demissie, S

Cupples, LA

Mendelsohn, ME

Levy, D

Housman, DE

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[2] UCL Royal Free & UCL Med Sch, Rayne Inst, Dept Med, Ctr Cardiovasc Genet, London, England

[3] Inst Child Hlth, Portex Anaesthesia Intens Therapy & Resp Med Unit, London, England

[4] Wofson Inst Prevent Med, MRC, Cardiovasc Res Grp, London, England

[5] Genom Collaborat, Cambridge, MA USA

[6] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[7] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[8] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

[9] Tufts Univ, New England Med Ctr, Boston, MA 02111 USA

[10] NHLBI, Framingham Heart Study, Framingham, MA USA

来源：

CIRCULATION RESEARCH | 2006年 / 98卷 / 05期

关键词：

genetics; myocardial infarction; estrogen receptor; risk factors;

D O I：

10.1161/01.RES.0000210578.62102.a6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha(ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c. 454-397T > C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio = 1.44; P < 0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).

引用

页码：590 / 592

页数：3

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